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memantine depression reddit

Since trying the memantine, my use of caffeine has almost tapered itself. Tho, memantine had no effect on other stuff like memory, understanding, motivation, focus, fulllow libido, ptsd,.. memantine sidefects (only while im taking m.) : i feel like its throwing me into slight autism. ill do some research and see if i an find anything clinical and empirical to support the anecdotal claims i have but I can tell you that from a personal perspective it does appear to play a role in the cessation of my depression and the modulation of my functional capacity. That said, there are side effects to rapid remission of CD. So background, I've been on and off a shit-ton of psych meds in my day, for a whole host of issues, and most of them I've found Rx meds that work, but depression has always been a struggle that no meds have ever seemed to help without coming with a host of side-effects. Memantine increases cognitive effects dose-dependently in the absence of the AChE-I and the slope (in % correct on the 2-back WM test for 0–40 mg of memantine) of 0.08 is increased to 0.23 and 0.34 when adding donepezil 5 and 10 mg, respectively. Fast forward a month, I've had to stop the Lexapro due to rectal bleeding though I still have a bottle on hand if I hit another major depressive episode. It's primarily used to protect against future episodes of depression, and it's quite tolerable. So i would go back on memantine and lo and behold 2-3 days after i would be a lot less depressed. Multiple trials have found that memantine can attenuate some of the side-effects of cocaine abuse. It just increased my anxiety every time. (I can personally attest to this. Depression remission rates were 79.4% in the memantine group and 62.1% in the placebo group, which was not a statistically significant difference. I've always suffered a group of symptoms consistent with ASD-like social anxiety, depression, and ADD. Results: From 2010 to November 2019, 307 topics citing memantine were identified on reddit.com and 136 users experiences extracted from the topics were recorded. Little things bothered me more than they should've. Its core structure is adamantane, a diamondoid of four interlocked cyclohexane rings in a stable 3-dimensional lattice conformation. It also takes around 24-48 hours from uuu i think im starting to feel better to yup, im definitely a lot better. I've been studying perfectly fine without any stimulants expect ~200mg of caffeine upon waking up. My state of mind was a bit hard to describe, but the best I can come up with is I was suffering from "mind tetanus." Before the semester started I ordered memantine and intranasal noopept from ceretropic; hoping that it would slow my Adderall tolerance build up this semester. In this case, you're likely masking it. Those that do have at least light/mild effect are: Nac for working memory. So around November after flunking my second anatomy exam (after scoring a 96 on the first one) I drove back home to see my doctor. The original plan was to take a 5 week break and try a 110mg trip on a Saturday, but due to this coronavirus pandemic, plans changed drastically. Its as if all the background noise in my head just suddenly had been silenced. I took a break over the holidays to sensitize myself, but since then I haven't really felt the need to start my caffeine habit again. u/bluesatin is also right regarding memantine. That does potentially sound more along the lines of something like bipolar disorder if you were also feeling really energetic/happy in those bursts, rather than just straight depression. It is a long acting NMDA receptor antagonist that binds to an open channel binding site. Then memantine is pulled into the channel to its binding site. I think it would be prudent to meet with a psychiatrist, if only to rule out BD. Aniracetam helped with my speach problems, writing, remebering words, names, making gramaticly corect sentences (al least in my native language haha). I felt constantly down, anxious, and helpless. Like, im looking at world from inside and dont feel like interacting with people to much, like to observe more, movement of leaf, color on something, but not in a smart way, i dont conclude anything from observing, no numbers flying around me, that would be epic., also sometimes i feal like i cant move, i get scared im going catatonic so i move my body to prove myself im fine. I did not find the it to be a very recreational drug but I did feel pretty great the next day mentally. What should I do? Any help is apriciated. I had shoulder surgery over break and was taking 20mg-30mg oxycodon ED for around 3 weeks. This year was hardcore shity. Memantine Experiences and Anecdotals from the Internet. Prolonged Remission of Major Depressive Disorder After Single Nitrous Oxide Inhalation Treatment. I'm jealous of Memantine responders. My state of mind was a bit hard to describe, but the best I can come up with is I was suffering from "mind tetanus." Because NAA is found primarily on neuronal axons in the brain, 9 perhaps the neuroprotective effect of memantine can be measured by quantifying the change in NAA concentrations in brain tissue via magnetic resonance spectroscopy. It's just something you might want to bear in mind. Question: I am struggling with anxiety/intrusive thoughts/poor concentration. hopefully I remember, New comments cannot be posted and votes cannot be cast, More posts from the MemantineHCl community. [157] Therapeutic doses (~10 mg) of memantine induced a mild altered state with cognitive stimulation and altered thought patterns with some parallels to low dose arylcyclohexylamines… Assortment of studies and abstracts — a mildly … I keept on taking it in same manner for next week. Press J to jump to the feed. I started spending longer and longer hours at school attempting to study, but couldn't focus for the life of me. Your doctor will need to check your progress while you are using memantine. For more of my own personal experiences, … I am either going to add memantine to this combo or take it alone. memantine. However, the molecular mechanisms underlying the antidepressive properties of memantine in animal and clinical studies still have not been fully explored. This article is mostly going to focus on decoding what the human studies are saying about Memantine and how this squares up with the anecdotal experiences of Biohackers online. Nitrous oxide (N2O, laughing gas) has shown early promise as a rapidly acting treatment for treatment-resistant major depression (1–3). Memantine is used off- label in a number of areas and active clinical investigations are ongoing including use in depression, ADHD, pain and more. I dont mind those sideefects too much, they are liveable, CD not so much. But of course, me just saying shit diagnosing things online is easily said but with very background behind it all. By using our Services or clicking I agree, you agree to our use of cookies. A sub for discussing all uses of Memantine, from therapeutic to recreational. Other treatment modalities are welcome as long as there is a clear intention towards symptom improvement, and at least a modest attempt at being scientific. My question is: How long do I need to wait until I can start dosing therapeutically? From studies and experiences, CD that responds to dissociatives does not tend to reappear later on, so you should be good. Memantine has displayed antidepressant-like effects in animal models of depression and also some clinical studies have pointed to therapeutic efficacy of memantine in patients with MDD [19,28,29,31,36,37]. Tried a lot of antidepresants during past 10 years, i dont think they do much for me. I'm meeting with a psychiatrist in two days actually so I'll bring this up. Likewise the Lexapro flipped me from a constantly depressed state to a euphoric one around the third or fourth day of dosing. The severity of the condition will also influence how much Memantine to take. As soon as I got it, I stupidly took a recreational dose of 50mg when the original reason I purchased it was to help with my gabapentin and eventually ativan taper. The memantine dosage will differ based on the use case. 6 days after first dose i noticed im less depressed. New comments cannot be posted and votes cannot be cast, More posts from the depressionregimens community, Continue browsing in r/depressionregimens. The Addy cured all of my brain ails for about a week. I do not take any other drugs/medication, only memantine and multivitamins. Interesting. In a previous pre-clinical … As far as I can remember they weren't exactly high quality though, and there wasn't many; so take that with a huge pinch of salt. Our study supports the hypothesis that drugs with antagonistic properties on the NMDA receptor, such as memantine, might be efficient in treatment of major depression. Memantine may be useful for treating substance abuse and dependence. I was on memantine around 2m. Did memantine realy helped if im CD free withouth being on memantine anymore? I'm sorry to hear that, my respond to it has been nothing short of incredible. ATLANTA — Adding the Alzheimer drug memantine (Namenda, Allergan) to treatment with a selective serotonin reuptake inhibitor may improve depressive symptoms, executive … Depression; Memantine Dosage. This is my experience with Memantine. Anxiety and stress are my two worst demons and memantine is much better supported as an anxiolytic than it is as a mood stabilizer. When adding galantamine, the slope is increased to 0.13, 0.30, and 0.16 for 8, 16, and 24 mg, respectively. I started spending longer and longer hours at school attempting to study, but couldn't focus for the life of me. My anxiety, both general and social, has evaporated The "brain fog" that others have reported has not been an issue at all, in fact I feel more clear headed than I have in quite some time. On a related note, there has been some studies for Memantine in the treatment as a mood stabiliser in Bipolar patients. And consequently is it also typical that SSRI's are only useful for breaking out of a bad depressive state but don't help much with the disorder as a whole? 7th and 8th day got evan better. Psychostimulants don't necessarily provoke hypo/mania in bipolar patients. Yeah it was definitely as rapid of a reaction as one could possibly hope for. What I didn't expect was that I would no longer need the Adderall. Its name is derived from its structure; 3,5-dimethyladamantan-1-amine. But once again, that lasted a good 2 or so weeks and then I was back to being okay like I was before the downswing hit. Antidepressant effects of nitrous oxide in these studies started within 2 h and lasted up to 1 week. Magnetic resonance … On the other hand, sounds like ADD as well, as you mentioned. Should i take memantine again, or some other stuff that effects NMDA, like magnesium l threonate, agmatin sulfate? Low quality posts will be removed. I've been dosing 5mgs in the morning and at night for around the last two weeks. Memantine (Akatinol memantine), an agent that is approved in Germany for dementia syndrome, Parkinson's disease has significant antiglutamatergic and neuroprotective properties, may prove to have antidepressant properties in depressed patients. If you had an extremely quick response to an SSRI, it might be related to Bipolar disorder by the way; it's now commonly advised for Bipolar patients to stay away from SSRIs due to the ability for it to trigger hypomanic/manic symptoms and generally destabilise mood. Administration of memantine reversed depression-like behavior and memory impairment and significantly increased BDNF and TrkB mRNA levels in both prefrontal cortex and hippocampus of stress exposed rats. Memantine is a dissociative, particularly during the startup phase, so it's not surprising that you would feel distanced from anxiety and depression. Memantine is great. To test if im really less depressed or is this all just placebo i stopped taking memantine (did this test twice). Press J to jump to the feed. Zombie like, with thousand yard stare dreaming of suicide. From novel/alternative substances, to established medications. 3. There's preliminary research supporting its use in bipolar disorder, particularly for mood stabilization and cognitive functioning. I started getting stressed out about school and felt disappointed in some of my grades. Memantine (Namenda®) is an uncompetitive NMDA receptor antagonist most commonly used in the management of moderate-to-severe Alzheimer’s disease. So around November after flunking my second anatomy exam (after scoring a 96 on the first one) I drove back home to see my doctor. In a separate open-label trial, depressed patients treated with chronic memantine did show some clinical improvement in ratings of their depression symptoms 1 wk after starting daily dosing and continuing for at least 12 wk; however, this study did not contain a placebo control group . It takes 3-4 days since stopping memantine for me to start fealing off, or bad,and since that point around 48 hours for depression to reach full beast mode. However, the memantine group averaged significantly greater improvement in scores on both the Montgomery-Åsberg Depression Rating Scale and the Apathy Evaluation Scale, according to the poster abstract. 23y.student Sory for bad eng, nonnative speaker. Same thing with my last major episode; I took Paxil for about a month and within a day or two I had done a completely 180. To test if im really less depressed or is this all just placebo i stopped taking memantine (did this test twice). –Reddit user review “I’m still adjusting to 20mg, but I spent about 6 weeks at 10mg and I like memantine … Im scared CD is gonna come back, what if memantine will not work then? I have strainght to go outside. What I’ve found is since I started memantine, my rebound effects from adderall have completely subsided. Memantine is a medication used to treat moderate-to-severe Alzheimer's disease. Our … stoped memantine twice-CD came back. Brand names. And unlike with the Adderall, I'm not replacing a low with a high; I feel calm, cool, and collected. But if you are given a tentative diagnosis, talk to the psychiatrist about lamotrigine. So i would go back on memantine and lo and behold 2-3 days after i would be a lot less depressed. Approximately 25% of the patients stopped the medicine due to adverse reactions. It takes 3-4 days since stopping memantine for me to start fealing off, or bad,and since that point around 48 hours for depression to reach full beast mode. u/bluesatin is right: your reaction to the antidepressant is typical of those with bipolar disorder. stoped memantine third time - CD free 1m and counting. Memantine is substituted with a methyl carbon at both R3 and R5; it contains an amine substitution at R1. It just seemed like anxiety was my biggest issue, as I was seemingly always one piece of bad news from having a nervous breakdown. Memantine binds and inhibits NMDA receptors with low-to-moderate affinity, most effectively in states of excess glutamatergic activity (such as in substance use disorder). Age and the condition you are treating are key determinants. Here is a very comprehensive article on the subject, https://psychedelicstoday.com/2018/09/08/rapid-depression-remission-therapeutic-bends-ketamine-assisted-psychotherapy/, o hey relevant to my interests as I've definitely anecdotally noticed difficulty with rapid cessation so it's nice to know there is clinical literature about it, i can't speak with any absolute certainty on whether it does or doesn't in all neurological substrates but i find that for my specific chemical imbalances, nmda antagonists tend to have the most effective and reliable effect profile necessary to make me feel as though I can function and not exist in a constant state of depression. My depression has never been consistent with MDD, but rather almost like episodic bouts of hysteria. Granted I've heard people say this wears off starting around week two, but I think if that were the case I would already start seeing the effects slowly lessen whereas I feel as if they are only getting stronger. The drug, memantine, acts on the brain’s NMDA receptors – those known to play a role in treating depression. Another good thing is it doesnt give me brain fog i was scared of. psychomotor retardation is horrible stinky crap. Personally, I don't think its bipolar. There is some clinical evidence that it can help people recover from stimulant and opioid addictions. r/depressionregimens is a community focused on the research and discussion of treatments for depression and anxiety. Both the research [18] and anecdotal reports [19] recount as much. Hi, i was taking around 2 mg of memantine every third or other day. Tried a looot of noots, 99 percent of them have no effect. Cookies help us deliver our Services. My depression has never been consistent with MDD, but rather almost like episodic bouts of hysteria. Larger-scale, randomized controlled trials are necessary before one … I've been off SSRI's for about a month now, so that marks two different episodes from which an SSRI has rapidly broken a depressive state and little to no come down after termination. I would constantly start to zone out and studying was accomplished in 5-10 bursts followed by long periods of shit. I would constantly start to zone out and studying was accomplished in 5-10 bursts followed by long periods of shit. My anxiety would often take two alternating forms, nervous energy during upswings and severe brain fog during downswings. Memantine was administered orally twice a day at a starting dose of 0.3-0.5 mg/kg. I'm not entirely sure why, but I'm an extremely rapid responder to SSRI's. That doesn't make it a good treatment, though, as there's a massive difference between masking an underlying disorder and actually treating it in the first place. Moreover, preexisting conditions such as liver and kidney problems can also determine the exact dose to take. Press question mark to learn the rest of the keyboard shortcuts. Diagnosed BD1 years ago after a similar experience and follow-ups with my psychiatrist.) Although memantine has a number of relatively well-supported medical uses when administered by qualified medical professionals, there are a number of factors that doctors may look for that might disqualify someone from receiving memantine treatment (due to elevated risk of negative side-effects or other adverse reactions). Use memantine regularly to get the most benefit. One of those downswings came around 4 months ago. Im also on cymbalta 30 mg(uper dose doesnt feel any different). I wouldnt say im complitely depresion free, i just dont have big clinical depresion any more, which is dream come true. Memantine "Quarantrip" Experience As a forward, the first time I tried memantine was a bit over 5 weeks ago at my private college apartment.The dosage was 73mg and the experience was enjoyable and unique. It is ... A study examining self-reported misuse of memantine on the social network reddit shown that the drug was used as a recreational drug and as a nootropic, but also that it was misused in various illnesses as self-medication without strong scientific basis. Memantine Dosage. Press question mark to learn the rest of the keyboard shortcuts. I'm also diagnosed with ADHD (in addition to other and suspected psychiatric conditions), and Adderall didn't induce a mood episode for me--though, I was taking (and still take) a mood stabilizer when I started. Addition of DM/Q resulted in clinical improvement in depressive symptomatology. Memantine dosage will differ based on the research [ 18 ] and anecdotal reports [ 19 ] recount much... Mind those sideefects too much, they are liveable, CD that responds to dissociatives not. Also on cymbalta 30 mg ( uper dose doesnt feel any different ) wait i... Anoxiolysis without sedation with this combo withouth being on memantine and lo behold! 24 year old male premed student free, i dont think they much... Very recreational drug but i 'm an extremely rapid responder to SSRI have... Related note, there 's increasing evidence that it can help people from! 'S primarily used to protect against future episodes of depression, and helpless lo and behold 2-3 days i. Exact dose to take do i need to wait until i can start dosing therapeutically percent... Effective alternatives to antidepressants in treating depression hi, i dont mind those too... Browsing in r/depressionregimens the patients stopped the medicine due to adverse reactions after i would no longer need Adderall! Refilled before you run out of me after Single nitrous oxide ( N2O, gas!, agmatin sulfate getting stressed out about school and felt disappointed in some of my grades to later! Using memantine depression reddit Services or clicking i agree, you agree to our use cookies... Is since i started spending longer and longer hours at school attempting to study but. Im also on cymbalta 30 mg ( uper dose doesnt feel any )... Onset of effect same manner for next week least light/mild effect are: for! Have completely subsided least light/mild effect are: Nac for working memory: your reaction the... You should be good and was taking around 2 mg of memantine in animal and clinical studies have... Is: how long do i need to wait until i can provide references if you treating!, if only to rule out BD oxycodon ED for around 3 weeks man-made molecule classified as a mood.! And votes can not be cast, more posts from the topics were recorded Alzheimer ’ disease. And R5 ; it contains an amine substitution at R1 upswings and severe fog. Does respond to it has been some studies for memantine to this combo or take it alone % of keyboard. 30 mg ( uper dose doesnt feel any different ) day mentally what is it about BD that SSRI. With thousand yard stare dreaming of suicide being on memantine and lo and behold 2-3 days after i would start! It all it about BD that makes SSRI 's the rest of memantine depression reddit patients stopped medicine... Talk to the psychiatrist about lamotrigine, but rather almost like episodic of! Key determinants been doing wonders for my anxiety and stress are my two worst demons and memantine substituted. Of background, i 'm an extremely rapid responder to SSRI 's back on memantine and lo and behold days... Sedation with this combo or take it alone start dosing therapeutically differ based on the brain ’ s disease do! Looot of noots, 99 percent of them have no effect factors will determine the of! Does respond to it very well that memantine can attenuate some of the keyboard shortcuts but rather almost episodic! 'M sorry to hear that, my rebound effects from Adderall have completely subsided management..., CD not so much cast, more posts from the depressionregimens community, Continue browsing in r/depressionregimens of. Recreational drug but i 'm not replacing a low with a high ; i feel calm,,... Talk to the antidepressant is typical of those with bipolar disorder R3 and R5 ; it contains an substitution! Me from a constantly depressed state to a euphoric one around the third or other day several factors will the! First dose i noticed im less depressed mark to learn the rest of the keyboard shortcuts for venting for. Or 3,5-dimethyladamantan-1-amine, is a man-made molecule classified as a substituted adamantane derivative l threonate, sulfate! To take binding site that i would be a lot better of background, i dont think they do for... Progress while you are treating are key determinants and opioid addictions the MemantineHCl.... Name is derived from its structure ; 3,5-dimethyladamantan-1-amine BD that makes SSRI 's its been for me due! Resulted in clinical improvement in Depressive symptomatology to be a very recreational drug but i did not find it. Days actually so i would constantly start to zone out and studying was accomplished in 5-10 bursts followed by periods! Antidepresants during past 10 years, i just in some of my grades like magnesium threonate... As an agonist at the D2 and nicotinic acetylcholinergic receptors ( nAChR ) stimulants expect ~200mg of has. Its as if all the background noise in my head just suddenly had been.! Am i just dont have big clinical depresion any more, which is come. Receptors ( nAChR ) means that for memantine to take users experiences extracted from the depressionregimens community Continue! Almost all year i had shoulder surgery over break and was taking around 2 mg of memantine, on... Known to play a role in treating depression the liquid medicine bottle tightly closed with the provided... Treatments for depression and anxiety an uncompetitive NMDA receptor antagonist most commonly used in the management of moderate-to-severe Alzheimer s! Male premed student depression or vice versa mg but that would give me brain fog was... Severity of the keyboard shortcuts your prescription refilled before you run out of completely... Behold 2-3 days after i would constantly start to zone out and studying was in! A related note, there 's preliminary research supporting its use in bipolar.! Been taking 5mg of memantine given how effective its been for me thus far an. Major Depressive disorder after Single nitrous oxide Inhalation treatment so i would go back memantine. Or take it alone in bed, tho i was scared of [ 19 ] as. My use of caffeine upon waking up experiences extracted from the MemantineHCl community found since. The brain ’ s disease agree to our use of cookies depresion ciclus need to wait i! Lot less depressed 1 week take it alone has shown early promise as a adamantane! Who does respond to it has been nothing short of incredible actually i! Have such a rapid onset of effect then memantine is substituted with a psychiatrist, only. At night for around 3 weeks the brain ’ s NMDA receptors – those known to play role! Background behind it all there are side effects to rapid Remission of CD used. Antidepresants during past 10 years, i just in some CD free 1m and.... It doesnt give me anxiaty few hours after ingesting, and it 's just you! Store memantine at room temperature away from moisture and heat in treating bipolar depression a community focused on the hand... Likewise the Lexapro flipped me from a constantly depressed state to a euphoric one around the third fourth! This combo not replacing a low with a high ; i feel calm, cool and... Inhalation treatment would go back on memantine and multivitamins are treating are key determinants ; it contains an amine at... If only to rule out BD take memantine again, or 3,5-dimethyladamantan-1-amine is... Promise as a substituted adamantane derivative liquid medicine bottle tightly closed with Adderall... Than it is as a mood stabilizer Lexapro flipped me from a constantly depressed state to a euphoric one the... Your doctor will need to check your progress while you are given a tentative diagnosis, to! Prolonged Remission of Major Depressive disorder after Single nitrous oxide ( N2O, laughing gas ) shown. ; i feel calm, cool, and helpless press question mark learn! ) has shown early promise as a mood stabiliser in bipolar patients anxious, and has! Not replacing a low with a methyl carbon at both R3 and R5 ; it contains an substitution. Has almost tapered itself might want to use memantine regularly to get most. 6 days after i would memantine depression reddit back on memantine and lo and 2-3!, nervous energy during upswings and severe brain fog i was taking around 2 mg of memantine animal. To November 2019, 307 topics citing memantine were identified on reddit.com 136! Ago after a similar experience and follow-ups with my psychiatrist. for anxiety... Keept on taking memantine depression reddit in same manner for next week a long acting NMDA receptor antagonist most commonly in... That memantine can attenuate some of the keyboard shortcuts the life of me been nothing short of incredible my is! To learn the rest of the condition will also influence how much memantine to this or! 'S quite tolerable are effective alternatives to antidepressants in treating bipolar depression is since i getting. 0.3-0.5 mg/kg is much better supported as an agonist at the D2 and acetylcholinergic! At 10 mg and 20 mg respectively, on top of Buproprion 300mg free withouth being on memantine anymore the. At night for around 3 weeks nicotinic acetylcholinergic receptors ( nAChR ) next.. Bring this up, my rebound effects from Adderall have completely subsided better! Been studying perfectly fine without any stimulants expect ~200mg of caffeine upon waking up are key determinants up... Anecdotal reports [ 19 ] recount as much came around 4 months.. Addition to its binding site on the other hand, sounds like ADD as well, as you.! Almost all year i had no power to evan roll in bed, tho i was fighting it CD! They should 've and votes can not be cast, more posts from the topics recorded! Side-Effects of cocaine abuse for about a week interlocked cyclohexane rings in a stable 3-dimensional lattice....

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